AlphaFold was soon joined by RoseTTAFold, another protein modeling algorithm from a team led by the University of Washington’s David Baker, who shared the Nobel Prize with Hassabis and Jumper. Later generations of both algorithms have begun to dynamically model proteins, small molecules, DNA, and RNA. Meanwhile, Baker and others are pushing the frontier with ChatGPT-like algorithms fluent in the language of biology. Some of these generate designer proteins never seen before in nature; others produce whole genomes shown to work in viruses. Still more are dreaming up antibodies entering clinical trials and new systems of CRISPR gene editing.